Mattia Persano (born 21 September 1996) is an Italian football player who plays for Serie D club Notaresco.
He made his Serie C debut for Lecce on 14 September 2016 in a game against Catanzaro.
On 31 January 2020, he returned to Italy and signed with Rieti.
On 13 August 2020 he joined Turris.
On 17 December 2021, his contract with Vibonese was terminated by mutual consent. On 20 December 2021, he returned to Arezzo.