Matthews Run is a long 2nd order tributary to Brokenstraw Creek. It is classed as a cold water fishery by the Pennsylvania Fish and Boat Commission.
According to the Geographic Names Information System, it has also been known historically as:
Matthews Run rises in Warren County, Pennsylvania about 0.5 miles northeast of Pikes Rocks and flows southeast to meet Brokenstraw Creek at Youngsville.
Matthews Run drains of the Pennsylvania High Plateau province and is underlaid by the Venango Formation and the Corry Sandstone through Riceville Formation. The watershed receives an average of 45.0 in/year of precipitation and has a wetness index of 378.67. The watershed is about 69% forested.