Materazzi () is an Italian surname from Arezzo, Perugia and Lazio in central Italy as well as Salerno in southern Italy, either derived from a place name or originally indicating a mattress maker. Notable people with the surname include:
Daniel Materazzi (born 1985), Portuguese footballer, nicknamed after Marco
Giuseppe Materazzi (born 1946), Italian football player and manager, Marco's father
Marco Materazzi (born 1973), Italian football player and manager