Mary Virginia may refer to:
- Mary Virginia Carey (1925âÂÂ1994), English-born American writer
- Mary Virginia Cook Parrish (1862âÂÂ1945), American leader in Black Baptist Women's Conventions, clubwoman, educator, journalist, and civil rights activist
- Mary Virginia Duval (1850âÂÂ1930), American textbook author
- Mary Virginia Ellet Cabell (1839âÂÂ1930), American educator
- Mary Virginia Eshelman, birth name of Virginia E. Johnson (1925âÂÂ2013), American sexologist
- Mary Virginia Gaver (1906âÂÂ1991), American librarian
- Mary Virginia Gonzaga (died 1983), one of the Cassandra Martyrs of Charity
- Mary Virginia Harris (1911âÂÂ2004), American veteran of World War II
- Mary Virginia McCormick (1861âÂÂ1941), American philanthropist
- Mary Virginia Merrick (1866âÂÂ1955), American pioneer in U.S. Catholic social reform
- Mary Virginia Orna (born 1934), American color chemist, historian of science, and professor emerita
- Mary Virginia Orozco (1928âÂÂ2019), American lawyer
- Mary Virginia Proctor (1854âÂÂ1927), American journalist, philanthropist, and social activist
- Mary Virginia Taylor (born 1950), American retired Methodist bishop
- Mary Virginia Terhune (1830âÂÂ1922), American author
- Mary Virginia Wade (1843âÂÂ1863), known as Jennie Wade, American civilian killed in the American Civil War
- Mary Virginia Weber (1927âÂÂ2017), American politician