The Mary Baldwin University, Main Building is a historic building on the Mary Baldwin University campus in Staunton, Virginia. It was built in 1844, and is a Greek Revival style educational building. It consists of a two-story, five bay central section, flanked by three-bay two-story wings with full basement and projecting gable ends. The front facade features a four-bay portico with four Greek Doric order columns supporting a Doric entablature and pediment.
It was listed on the National Register of Historic Places (NRHP) in 1973.
Hilltop, C. W. Miller House, and Rose Terrace are other NRHP-listed buildings on the campus.