Marrakesh-Safi () is one of the twelve regions of Morocco. Its population in 2024 was 4,878,500. The capital is Marrakesh.
Marrakesh-Asfi was formed in September 2015 by merging the old region of Marrakesh-Tensift-El Haouz with the provinces of Asfi and Youssoufia in Doukkala-Abda region.
In September 2023 the region was struck by a large magnitude 6.9 earthquake that reportedly left over 2,800 people dead and injured more than 3,000 others.
On 19 October 2025, Khatib El Hebil was appointed Wali of the Marrakesh-Safi region and Governor of the Marrakesh prefecture by King Mohammed VI, during a Council of Ministers meeting in Rabat.
The region is made up of the following provinces and prefectures: