Mark Kofi Sekyere (born 28 December 1989) is a Ghanaian former footballer who played as a midfielder.
Sekyere was born in Kumasi. He began his career by Feyenoord Academy, joined than on 12 June 2008 to Asante Kotoko, after a half year with Kumasi joined to ASEC Mimosas in January 2009. After three season with ASEC Mimosas returned to his home club Feyenoord Academy.
On 4 December 2008, Sekyere was nominated for the African Cup of Nations Qualifier 2009 for the Black Stars and played his debut on 19 November 2009 against Angola.