Mario Ardissone (; 9 October 1900 â 1975) was an Italian footballer who played as a midfielder.
Ardissone played for 6 seasons (161 games, 6 goals) in the Italian Serie A for U.S. Pro Vercelli Calcio. Ardissone made his debut for the Italy national football team on 20 January 1924 in a game against Austria. He was also part of Italy's squad at the 1924 Summer Olympics, but he did not play.