Marginella desjardini is a species of sea snail, a marine gastropod mollusk in the family Marginellidae, the margin snails.
The shell has a distinct reddish pink colour, with an obovate shape and light spots around the exterior. The lip around the aperture has distinct ridges. This species attains a length of 72 mm.
This marine species occurs in Eastern Atlantic waters, off Senegal, West Africa.