Marco Padalino (born 8 December 1983) is a Swiss former professional footballer who played as a midfielder. He played for Malcantone Agno, Catania, Piacenza, Sampdoria and Vicenza, and Lugano. A Swiss international from 2009 to 2014, he represented Switzerland at the 2010 and 2014 FIFA World Cups. Originally an attacking midfielder, he played as a winger in his later career.
Padalino was born in Switzerland and is of Italian descent.