Manzac-sur-Vern (; ) is a commune in the Dordogne department in Nouvelle-Aquitaine in southwestern France.
There are near the town both prehistoric Gallo-Roman traces. In the Middle Ages, Manzac had a former Priory of the Abbey of Brantôme and on November 27, 1911, the commune of Manzac was renamed Manzac-sur-Vern
Significant landmarks include the Saint-Pierre-ès-links a 15th-century church with façade (shown right) dating from the 19th century and Gothic bell tower.