Lee Manuel Ossie (born July 18, 1968) is a Liberian former professional boxer. Nicknamed "Destroyer", Ossie is a former European Union light heavyweight and African heavyweight champion.
On August 26, 2005 Manuel upset title contender Adewale Abbey to win the African Boxing Union heavyweight title.
Ossie lost to undefeated American Chris Arreola. The bout was televised on ESPN.