The Rural Municipality of Mankota No. 45 (2016 population: ) is a rural municipality (RM) in the Canadian province of Saskatchewan within Division No. 3. Located in the southwest portion of the province, it is adjacent to the United States border, neighbouring Valley County and Phillips County in Montana.
The RM of Mankota No. 45 incorporated as a rural municipality on January 1, 1913.
The following urban municipalities are surrounded by the RM.
The following unincorporated communities are within the RM.
In the 2021 Census of Population conducted by Statistics Canada, the RM of Mankota No. 45 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
In the 2016 Census of Population, the RM of Mankota No. 45 recorded a population of living in of its total private dwellings, a change from its 2011 population of . With a land area of , it had a population density of in 2016.
The RM of Mankota No. 45 is governed by an elected municipal council and an appointed administrator that meets on the second Tuesday of every month. The reeve of the RM is Greg Zerr while its administrator is Tammi Baldock. The RM's office is located in Mankota.