Manistee High School is a public secondary school in Manistee, Michigan, United States. It serves grades 6-12 for the Manistee Area Public Schools.
Manistee's Mariners compete in the West Michigan Conference. School colors are Navy blue and gold. The following Michigan High School Athletic Association (MHSAA) sanctioned sports are offered:
Prior to 2023, the school's teams were known as the "Chippewas". The school retired the indigenous nickname in favor of the name "Mariners".