Mandelstam or Mandelshtam () is a Jewish surname which may refer to:
- Leonid Mandelstam (1879âÂÂ1944), Russian theoretical physicist
- Mandel'shtam (crater), lunar crater named for Leonid Mandelstam
- Nadezhda Mandelstam (1899âÂÂ1980), Russian writer, wife of Osip Mandelstam
- Osip Mandelstam (1891âÂÂ1938), Russian poet
- Leon Mandelshtam (1819 â 1889), Russian poet and translator
- Rod Mandelstam (born 1942), South African-born tennis player
- Stanley Mandelstam (1928âÂÂ2016), South African-born particle physicist
- Mandelstam variables, relativistically invariant representation for particle scattering, introduced by Stanley Mandelstam