Manaquiri is a municipality located in the Brazilian state of Amazonas.
Its population was 33,049 (2020) and its area is 3,976 km<sup>2</sup>.
Manaquiri is located in a portion of the southern Várzea forest of the Amazon River. The main waterway of the Amazon is located around 8 km (5 mi) north of the municipality.
By road, Manaquiri is connected via the highway.