Manandriana District is a district in central Madagascar. It is part of Amoron'i Mania Region. It covers an area of 981.98 km<sup>2</sup>, and had a population of 111,693 in 2020. Its capital is Ambovombe Afovoany. The name of the district comes from the Kingdom of Manandriana.
The district is further divided into ten communes: