For the rural municipality, see Manambolo (disambiguation)
The Manambolo River is a river in the highlands of western Madagascar of 370 km. It crosses the Tsingy de Bemaraha Strict Nature Reserve and the Maningoza Reserve.
The unpaved Route nationale 8 (Madagascar) crosses this river by ferry.
This river flows through Tsiroanomandidy, Bekopaka, Ambakaka, Ankaramena, Ankavandra and Soaloka.