Manafwa District is a district in the Eastern Region of Uganda. Manafwa is the district headquarters.
Manafwa District is bordered by Bududa District to the north, Kenya to the east and south, Tororo District to the south-west, and Mbale District to the west. The district headquarters at Manafwa are located approximately , by road, south-east of Mbale, the largest city of in the sub-region. County and sub county of Manafwa District.
This county has the biggest number of sub county in Manafwa District and they include:
The sub county for butiru county include:
Manafwa District was created in 2005. Previously, it was part of Mbale District, together with Sironko District. The total surface area of the district is estimated at . In 2006, the northern part of Manafwa District was carved off to form Bududa District. It is made up of 1 county and 18 rural sub-counties, 4 town councils, 3 traditional divisions (Buwagogo, Bugobero and Butiru), 81 parishes and 862 villages.
In 1991, the national population census estimated the district population at 178,500. The 2002 census estimated the population at 262,600 inhabitants. In 2012, the population was estimated at 367,500. In 2014, the population was 149,544, and In 2024, the population was 186,917.