Malignant refers to malignancy, the tendency of a medical condition to become progressively worse.
Malignant may also refer to:
- Malignant (2013 film), an American horror film directed by Brian Avenet-Bradley
- Malignant (2021 film), an American horror film directed by James Wan
- , an episode of Law & Order: Criminal Intent
- ', a 2013 book by S. Lochlann Jain
See also