Malesco () is a comune (municipality) in the Province of Verbano-Cusio-Ossola in the Italian region Piedmont, located about northeast of Turin and about north of Verbania, the provincial capital. As of 31 December 2004, it had a population of 1,478 and an area of .
Malesco is the most populous comune in Val Vigezzo and has a station on the DomodossolaâÂÂLocarno railway which runs along the valley. The neighbouring municipalities are: Cossogno, Craveggia, Re, Santa Maria Maggiore, Trontano, Valle Cannobina, Villette.