Maharat Nakhon Ratchasima Hospital () is the main hospital of Nakhon Ratchasima Province, Thailand and is classified under the Ministry of Public Health as a regional hospital. It is the largest regional hospital in Thailand under the responsibility of the ministry and has 1,478 beds. It has a CPIRD Medical Education Center which mainly trains medical students in the MOPH-Mahidol CPIRD Program of Mahidol University, as well as being an affiliated hospital to the Faculty of Medicine Ramathibodi Hospital, Mahidol University and Phramongkutklao College of Medicine.
Following the setup of sukhaphiban in Nakhon Ratchasima Province under the reign of King Chulalongkorn, two hospitals were built in the local area:
Sukhaphiban 1 Hospital was then merged into Sukhaphiban 2 Hospital and renamed <nowiki/>'Suan Mon Hospital'.
On 1 February 1935, Suan Mon Hospital was transferred from the responsibility of Sukhaphiban Hospitals Organisation to Nakhon Ratchasima City Municipality and the hospital was renamed <nowiki/>'Nakhon Ratchasima City Municipality Hospital'<nowiki/>. On 1 September 1954, operations were transferred to the Ministry of Public Health and renamed <nowiki/>'Nakhon Ratchasima City Hospital'<nowiki/>, and was categorised as a provincial hospital. In 1974, the hospital was re-categorised as a regional hospital. On 5 September 1981, the hospital was renamed by the Ministry of Public Health as <nowiki/>'Maharat Nakhon Ratchasima Hospital' in honour of King Bhumibol Adulyadej.