Madignano (Cremasco: ) is a comune (municipality) in the Province of Cremona in the Italian region Lombardy, located about southeast of Milan and about northwest of Cremona. As of 31 December 2006, it had a population of 2,977 and an area of .
The municipality of Madignano contains the frazione (subdivision) Ripalta Vecchia.
Madignano borders the following municipalities: Castelleone, Crema, Izano, Ripalta Arpina, Ripalta Cremasca.
Madignano is served by the Madignano railway station on the TreviglioâÂÂCremona line.