Macromphaliinae is a subfamily of the moth family Lasiocampidae. The subfamily was first described by John G. Franclemont in 1973.
Genera
- Apotolype <small>Franclemont, 1973</small>
- Artace <small>Walker, 1855</small>
- Hypopacha <small>Neumoegen & Dyar, 1893</small>
- Macromphalia <small>C. & R. Felder, 1874</small>
- Mesera <small>Walker, 1855</small>
- Titya <small>Walker, 1855</small>
- Tolype <small>Hübner, [1820]</small>
- Tytocha <small>Schaus, 1924</small>