Mackinac Trail, or Mackinaw Trail is the name for two related, but separate, roadways in the US state of Michigan.
- In the Upper Peninsula:
- , previous designation of H-63, before the construction of the I-75 freeway
- , the entire road between St. Ignace and Sault Ste. Marie
- In the Lower Peninsula:
- , between Petoskey and I-75 south of Mackinaw City
- Old , between Reed City and Petoskey.