In enzymology, a lysine N-acetyltransferase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are acetyl phosphate and L-lysine, whereas its two products are phosphate and N<sup>6</sup>-acetyl-<small>L</small>-lysine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-phosphate:L-lysine N6-acetyltransferase. Other names in common use include lysine acetyltransferase, and acetyl-phosphate:L-lysine 6-N-acetyltransferase. This enzyme participates in lysine degradation.