Lysergic acid methylamide (LAM), also known as N-methyllysergamide (NM-LA), is a serotonin receptor modulator of the lysergamide family. It is the N-methyl derivative of ergine (lysergic acid amide; LSA) and the analogue of lysergic acid diethylamide (LSD) in which the N,N-diethyl groups have been replaced with one N-methyl group.
It is active in humans at a dose of approximately 500üg and has roughly 20% of the potency of LSD as a drug. However, it has been said to produce autonomic effects but to produce no psychoactive or hallucinogenic effects at this dose. The drug has about 6.3% of the antiserotonergic potency of LSD in the isolated rat uterus in vitro.
LAM was first described in the scientific literature by Albert Hofmann and colleagues by 1955.