Lyantonde General Hospital, also Lyantonde District Hospital or Lyantonde Government Hospital, is a hospital in the Central Region of Uganda.
The hospital is off of the Masaka-Mbarara Road, in the town of Lyantonde in Lyantonde District, approximately , by road, east of Mbarara Regional Referral Hospital. This is about west of Masaka Regional Referral Hospital. The coordinates of Lyantonde General Hospital are 0ð23'56.0"S, 31ð09'13.0"E (Latitude:-0.398889; Longitude:31.153611).
Before 2011, Lyantonde General Hospital was a Health Centre IV. In 2011, the health center was elevated to a full hospital. Lyantonde General Hospital is on the list of general hospitals earmarked for renovation and expansion.