Luthersburg is an unincorporated community in Clearfield County, Pennsylvania, United States. The community is located at the intersection of U.S. routes 219 and 322, and Pennsylvania Route 410, south-southeast of DuBois. Luthersburg has a post office, with ZIP code 15848.
The community was named for W. H. Luther, an early settler.
The United States Census Bureau defined Luthersburg as a census designated place (CDP) in 2023.