Luther W. Clarke (c. 18251869) was a Michigan politician.
Clarke was born in about 1825 in Marietta, Ohio. In 1847, Clarke settled in Eagle River, Michigan.
Clarke was a physician. On November 2, 1852, Clarke was elected to the Michigan Senate, where he represented the 32nd district from January 5, 1853 to December 31, 1854. During his term, he served on the Mines and Minerals committee and the State Library committee.
Clarke died in 1869.