Lulu is an unincorporated community in Columbia County, Florida, United States. Lulu is located on State Road 100, east-southeast of Lake City. The former right-of-way for the Georgia Southern and Florida Railway runs along the south side of SR 100 in Lulu.
A post office called Lulu was established in 1891, and remained in operation until being discontinued in 1976. Lulu was the name of the first postmaster's love interest.