Luisa Grube (born 20 May 2001) is a German visually impaired paraclimber and former para-alpine skier
In January 2025, Grube competed at the 2025 Winter World University Games in para-alpine skiing and won a silver medal in the giant slalom event with a time of 2:58.40. She announced that challenges in finding a guide led to her decision to retire from competitive skiing, allowing her to focus on paraclimbing.
In September 2025, she competed at the 2025 IFSC Paraclimbing World Championships and won a bronze medal in the B2 event. Grube and Linda Le Bon both reached hold 37+, but due to her better qualification performance Le Bon won the silver medal.