Luis Antonio de Castro y Castillo (died 1653) was a Roman Catholic prelate who served as Bishop of La Paz (1647âÂÂ1653).
Luis Antonio de Castro y Castillo was born in Alcala la Real. On 13 September 1647, he was selected as Bishop of La Paz and confirmed by Pope Innocent X on 13 January 1648. On 26 April 1648, he was consecrated bishop by Juan de Arguinao y Gutiérrez, Bishop of Santa Cruz de la Sierra. He served as Bishop of La Paz until his death on 7 October 1653.