Louis J. and Harriet Rozier House is a historic home located at De Soto, Jefferson County, Missouri. It was built in 1887, and is a two-story, asymmetrical, Queen Anne style frame dwelling. It sits on a rock-faced limestone foundation and has a hipped roof and lower cross gables. It features a one-story wraparound porch, spindlework, and fishscale shingles.
It was listed on the National Register of Historic Places in 2006.