Lost Creek is a tributary of the south fork of Little Butte Creek in Jackson County in the U.S. state of Oregon. Flowing north from near Lost Lake east of Medford, it enters the larger stream about upstream of the rural community of Lake Creek and about from the confluence of Little Butte Creek with the Rogue River. The only named tributary of Lost Creek is Coon Creek, which enters from the .
Lost Creek Bridge, a covered bridge, carries Lost Creek Road over the creek but is closed to vehicular traffic. The structure is the shortest covered bridge in Oregon. It was added to the National Register of Historic Places in 1979.