Lorenzo Centurione (Genoa, 1645 - Genoa, 1735) was the 143rd Doge of the Republic of Genoa and king of Corsica.
On 26 September 1715, the Grand Council elected him as the new doge of the Republic of Genoa, the ninety-eighth in biennial succession and the one hundred and forty-third in republican history. As doge, he was also invested with the related biennial office of king of Corsica. Once the mandate ended on 26 September 1717, Lorenzo Centurione held other public offices. He died in Genoa around 1735.