Lorenzo is a census-designated place in Cheyenne County, Nebraska, United States. As of the 2020 census, Lorenzo had a population of 36. Lorenzo is located on Nebraska Highway 19, southwest of Sidney, the county seat, and north of the Colorado border.
Lorenzo was a depot on the Chicago, Burlington and Quincy Railroad. A post office was established at Lorenzo in 1916, and remained in operation until it was discontinued in 1933.