Lodovico Saffiro (died November 1635) was a Roman Catholic prelate who served as Bishop of Squillace (1635).
On 17 September 1635, Lodovico Saffiro was appointed during the papacy of Pope Urban VIII as Bishop of Squillace. On 21 September 1635, he was consecrated bishop by Giulio Cesare Sacchetti, Cardinal-Priest of Santa Susanna. He served as Bishop of Squillace until his death in November 1635.