Locust Creek is a stream in Morgan County in the U.S. state of Missouri. It is a tributary of Gravois Creek.
The stream headwaters arise at adjacent to the west side of Missouri Route 132 at an elevation of . The stream flows to the east under Route 132 and continues for a distance of approximately five miles to its confluence with Gravois Creek at and an elevation of .
Locust Creek was so named on account of locust timber near its course.