Lizaan du Plessis (born 23 February 1986) is a former professional tennis player from South Africa.
Born in Somerset East on the Eastern Cape, du Plessis made her Fed Cup debut for South Africa in 2005 and went on to feature in a total of ten ties.
She won seven titles on the ITF Women's Circuit, one in singles and six in doubles.
At the 2007 All-Africa Games in Algiers, she won silver medals in both singles and doubles events.