The Little Wekiva River is a stream in the Greater Orlando area of Florida in the United States. The long, northward flowing stream is a tributary of the Wekiva River, which later joins the St. Johns River, the longest river in the state of Florida. The Little Wekiva drainage basin is about located in the urbanized area north and west of Downtown Orlando.
As of 2021, much of the Little Wekiva River has silted up.
Little Wekiva is part of the middle basin of the St. Johns River. The St. Johns River Water Management District place the headwater of the creek at Lake Lawne, about northwest of downtown Orlando. The Geographic Names Information System (GNIS), though, list the source of the river at Spring Lake, an spring-fed lake in Altamonte Springs, Florida.