Little St. Lawrence is a local service district and designated place in the Canadian province of Newfoundland and Labrador.
The first postmistress was Mrs. Mary Clarke.
Little St. Lawrence is in Newfoundland within Subdivision F of Division No. 2.
As a designated place in the 2016 Census of Population conducted by Statistics Canada, Little St. Lawrence recorded a population of 117 living in 47 of its 62 total private dwellings, a change of from its 2011 population of 125. With a land area of , it had a population density of in 2016.
Little St. Lawrence is a local service district (LSD) that is governed by a committee responsible for the provision of certain services to the community. The chair of the LSD committee is Karen Lundrigan.