Little Buffalo Creek is a long 2nd order tributary to the Deep River in Lee County, North Carolina.
Little Buffalo Creek rises in Sanford, North Carolina and then flows north to the Deep River about 2 miles east-northeast of Farmville, North Carolina.
Little Buffalo Creek drains of area, receives about 47.6 in/year of precipitation, and has a wetness index of 458.86 and is about 35% forested.