St. Petersburg is the fifth largest city in Florida with a population of 258,308 as of 2020. As of 2024, the city is home to 64 completed high-rises, out of which 8 are over tall.
One St. Petersburg is currently the tallest building in the city since 2009 at , though the Residences at 400 Central topped-out in 2024. Bayfront Tower was the first to surpass the mark. Priatek Plaza, built in 1990, held the record for the tallest building in the city for 29 years, before being surpassed by One St. Petersburg. Signature Place, currently the fourth tallest building on the city at , has been credited for being a major transition in St. Petersburg modern architecture and surviving the 2008 financial crisis.
St. Petersburg has recently seen an economic boom in luxury condos dating from the 1990s to early and late 2000s. The combination of tourism and wealthy residents attracted wanted large and mid sized condominiums.
In 2024, the first building over topped-out, the 46-floor Residences at 400 Central, at . On October 10th, 2024, one of its tower cranes collapsed during Hurricane Milton.
In 2025, the Waldorf Astoria announced that it will build the tallest building in Saint Petersburg, rising 50 stories at 539 feet.
This list ranks the tallest completed and topped out buildings in St. Petersburg, Florida that are multistoried and over tall.