Clayton is the 44th largest city in Missouri and the county seat of St. Louis County, Missouri. The city has a population of 17,512 people as of 2025. The city has 11 high-rises which stand over tall. As of January 2026, the tallest building in Clayton is Centene Plaza C which stands tall.
This list ranks buildings in Clayton that stand at least tall. Spires and other architectural details are included in the height of a building, however, antennas are excluded.
There are no buildings in Clayton under construction which stand over .