This is a list of mayors of the 50 largest cities in the United States, ordered by their populations as of July 1, 2022, as estimated by the United States Census Bureau. These 50 cities have a combined population of 49.6 million, or 15% of the national population.
Honolulu, Indianapolis, Jacksonville, Louisville, and Nashville have consolidated city-county governments where the mayor is elected by residents of the entire county, not just that of the city proper; in these cases the population and respective rank are for the whole county.
In some jurisdictions, mayors are officially elected on a nonpartisan basis; however, the candidate's party affiliation that is known through their political history, self-declaration, or state party support is listed below.
The breakdown of mayoral political parties is 40 Democrats, 7 Republicans, 2 Independents (one elected with state Democratic support) and 1 unknown.