The ambassador of Russia to Guinea-Bissau is the official representative of the president and the government of the Russian Federation to the president and the government of Guinea-Bissau.
The ambassador to Guinea-Bissau and his staff work at large in the Russian embassy in Bissau. The current Russian ambassador to Guinea-Bissau is , incumbent since 9 March 2016.
Diplomatic relations between the Soviet Union and Guinea-Bissau were established on 6 October 1973, shortly after its declaration of independence from Portugal. Relations were initially handled through the Soviet embassy in Guinea, with the Soviet ambassador to Guinea, , having dual accreditation to Guinea-Bissau from 25 April 1974. The embassy in Bissau was opened in 1975, and the first ambassador solely accredited to Guinea-Bissau, , was appointed on 11 February 1975. With the dissolution of the Soviet Union in 1991, Guinea-Bissau recognised the Russian Federation as its successor state on 31 December 1991. The incumbent Soviet ambassador, , continued as ambassador from Russia until 1996. Russian citizens and embassy staff were evacuated from Guinea-Bissau in 1998 due to fighting between government and rebel forces during the Guinea-Bissau Civil War. The embassy resumed operating in February 2001.