There are 54 areas with over a thousand square miles of land under management of the Mississippi Department of Wildlife, Fisheries, and Parks and operated as Wildlife Management Areas (WMAs) in six regions:
Chronic Wasting Disease has been discovered in Alcorn, Benton, Carroll, DeSoto, Lafayette, Leflore, Grenada, Issaquena, Lee, Marshall, Panola, Pontotoc, Prentiss, Quitman, the southern half of Sharkey, Sunflower, Tallahatchie, Tate, Tippah, Union, Warren, and Yalobusha, counties.