The following is a list of main, recurring, supporting, notable and minor characters appeared in The Blood Sisters (TV series), a Filipino drama television series created and developed by Reggie Amigo and Rondel P. Lindayag and produced by ABS-CBN. The series premiered on February 12, 2018 on the network's prime time block, 5:40 or 6:00 p.m. time slot, and on worldwide via The Filipino Channel. The series is under the helm of Jojo A. Saguin and Catherine Grace Abarrando and Roselle Soldao-Ganaban serves as the executive producer for the entire run of the show.
Erich Gonzales stars as the triplets, main character lead portraying three characters with distinct personalities: shy-type young mother from the province, a promising surgeon from an elite family and an aggressive, foul-mouthed social climber. Erich plays Erika, a simple meek girl but feisty and aggressive when provoked. She also plays Carrie, a socialite, cool person with a calm personality. And finally, Agatha, cold-hearted and a gold digger who wants to become rich and powerful. Enchong Dee, AJ Muhlach and Ejay Falcon stars as the leading man. While, Maika Rivera star as another villain.