List of NFL career interceptions thrown leaders

The following list shows the NFL players who have thrown the most career interceptions:

Regular season career interceptions thrown leaders

Based on 200 Career Interceptions

• Y. A. Tittle also threw 27 interceptions while playing for the defunct Baltimore Colts Franchise of the All-America Football Conference in 1948 & 1949, but those stats were not included until 2025.

Playoff leaders

Statistics accurate as of the end of 2025–26 NFL playoffs

Based on 15 Career Interceptions

References